Skip to main content

NITE-OUT II Starter Bacteria

  • Fast and safe start of every aquarium
  • Specially developed bacterial mix
  • Living cold water bacteria - ready for use
  • Safely removes ammonium/ammonia & nitrite
  • Reduces losses of fish, corals, sponges and shells
  • Bacteria cultures for a natural biochemical metabolization: Nitrosomonas, Nitrospira & Nitrobacter
  • Without the addition of synthetic substances for water treatment

Saltwater & Freshwater
Removes ammonia
Removes nitrite
Living bacteria


Nite-Out II is a specially developed bacterial blend of purely biological ingredients that accelerates and perfects the establishment and upkeep of marine and freshwater aquariums.



It ensures optimally functioning nitrification in the aquarium rapidly and lastingly: NH3 ammonia / NH4 ammonium –> NO2 nitrite –> NO3 nitrate



Together with Special Blend, Nite-Out II replaces the “classic” run-in method and ensures that fish can be stocked quickly and safely.



It is used at the start of an aquarium and subsequently, typically after major water changes and for new stocking.


Dosage incl. dosage calculator

Your aquarium
(net volume of water in litres)

New Aquarium 10 ml per 100 L daily
When changing the water or new stock 10 ml per 100 L

Dosage (new aquarium):
Add 10 ml daily to 100 litres of water until ammonium/ammonia/nitrite is no longer measurable.

Dosage (maintenance & care):
Add a one-time dose of 10 ml to 100 litres of water after each water change or re-population with new animals.

FAQ Questions and answers

As the name suggests, Nite-Out II starter bacteria are used to start a saltwater or freshwater aquarium. It contains nitrifying bacteria that convert ammonium/ammonia into nitrite and then into nitrate. Nite-Out II should be dosed daily from the first day of an aquarium until the ammonium/ammonia and nitrite levels are within an acceptable range for the fish. Since as soon as you use fish, the values ​​​​of course increase again. In this case, you should continue with the daily dosage until these values ​​are also within a range that the fish can tolerate. We then recommend dosing Nite-Out II after larger water changes or when restocking with animals.

MICROBE-LIFT® Special Blend – ‘Nitrate reducer and cyano-killer’

This product deals with the first and last stage of nitrification. It contains microorganisms that break down coarse waste materials such as proteins, fats, detritus to make it easier for the traditional filter bacteria (Nitrosomonas sp., Nitrobacter sp. and Nitrospira sp.) to break down these substances. It allows them to work much more effectively. It also contains facultative aerobic and anaerobic bacteria that primarily break down nitrate into harmless nitrogen in oxygen-poor zones – particularly effective in DSB systems, but also in normal aquarium systems with living rocks. Furthermore, it contains photosynthetically activated purple sulphur bacteria, which are mainly used in the initial phase after dosing to suppress cyanobacteria.

Does MICROBE-LIFT Special Blend also help against cyanobacteria? And if so, why?

Cyanobacteria have a negative impact by destroying the settlement area for filter bacteria and inhibiting their growth. In order for sand grains and surfaces of the living rock to be re-colonised with filter bacteria, the cyanobacteria must first be eliminated. This is accomplished by the purple sulphur bacteria. They disappear after some time and thus make room for filter bacteria, which are added a few days later by the second MICROBE-LIFT product: Nite-Out II. As purple sulphur bacteria live photosynthetically, they are a serious competitor to cyanobacteria, especially during the day, and inhibit them until filter bacteria have grown back. They do not compete with filter bacteria because they carry out photosynthesis like zooxanthellae.

MICROBE-LIFT® Nite-Out II – ‘The traditional filter bacteria’

This product supplies the traditional filter bacteria (Nitrosomonas sp., Nitrobacter sp., Nitrospira sp.). It contains additional subspecies of these strains and has been designed to promote growth of natural filter bacterial grass, which guarantees fast decomposition of ammonium and nitrite. This helps considerably shorten the start-up phase of a newly set-up aquarium or to reduce fish losses during transport and aquarium relocation or conversion measures. Works immediately and reliably! Remains active down to 4 °C! (optimum temperature from 13 °C). Therefore, also suitable for cold water aquariums (Atlantic, Mediterranean, etc.).

The bacteria act immediately when used without first ‘waking up’ – unlike products based on trace elements. It is odourless and safe to use.

It is also important to test the pH value first and whether there is enough carbonate hardness. The CH value must always be at least 3 dH°. This is extremely important because the nitrifying bacteria consume it as fuel. Seven parts carbonate hardness are consumed for one part ammonium! Without good CH values, nitrification is also not possible! To increase the CH value, you can use the MICROBE-LIFT CH-Booster until you reach a value of at least 3–6 dH°.

MICROBE-LIFT Substrate Cleaner – ‘Silt, Detritus and PO4 Removal’

Contains natural brackish water silt from mangrove zones, which contains natural cellulose, mud, phosphate-binding iron oxides and special detritus-degrading and PO4-binding filter bacteria. The mud component is somewhat related to Miracle Mud in terms of consistency. With proper dosing, the water in the aquarium immediately becomes dark brown and turbid, then light brown and clear. The next day (at the latest, however, on the third day), it turns crystal clear and usually contains much less PO4. Coarser substrate becomes cleaner and detritus gradually disappears – especially in the gamma corners.

Recommended for use with all other MICROBE-LIFT bacteria and enzyme products.

MICROBE-LIFT Thera P – ‘therapeutic fish agent’

MICROBE-LIFT Thera P stimulates the immune system of the fish through probiotic bacterial strains which settle in the intestinal tract of the fish and thus ensure a healthy intestinal flora. Freshly imported fish (especially surgeonfish and some sensitive gobies), which are often weakened by the long transport route and/or have a severely damaged intestinal flora due to antibiotics, can be treated successfully with MICROBE-LIFT Thera P. Reduces downtimes to a minimum. Moreover, the entire aquarium environment is biologically stabilised, as it still contains approx. 50% of the product MICROBE-LIFT Special Blend, which reduces waste products, food residues and nitrate. It has long been a product used in fish farming in the USA. In this country it is recommended by seahorse and discus breeders. Due to the dual mode of action, it is especially recommended for breeding or retailer tanks, where many animals collide in a short time in a confined space. It also contains an herbal anti-stress agent and other selected bacteria, which in turn eat pathogenic germs or inhibit their reproduction.

Note: As it also contains a little bit of ‘Special Blend’, it may smell a little like hydrogen sulphide. It can be used prophylactically to prevent many diseases. Some aquarium enthusiasts have treated powder-blue surgeonfish with it for a week during their acclimatisation in their reef aquarium. The surgeonfish have now been in the aquariums for a year without ever having had any spots or other complaints. They are well fed. No UV system or ozone was used during the acclimatisation or later. This is quite a remarkable result for us, as most of these surgeonfish in the retailer’s tank were known to have had spots – despite UV exposure.

Seahorse breeders are amazed at the low loss rate of their seahorse youngsters when they are using MICROBE-LIFT Thera P.

Use directly in the aquarium according to the dosage instructions.

MICROBE-LIFT® is 100% harmless to humans, animals and plants. It is neither toxic nor pathogenic (disease-causing).

The MICROBE-LIFT® products do not work if pesticides or chemical algae killers are used. Please turn off UV lamps and ozone devices for 3 to 5 days for best results.

Yes, heavy metals in saltwater and freshwater aquariums ensure that bacteria almost completely stop important biological processes such as nitrification (conversion of ammonium/ammonia into nitrite and then nitrate) and denitrification (conversion of nitrate into nitrogen).

Unopened, you can store any of our MICROBE-LIFT bacterial products at room temperature. Only our product MICROBE-LIFT Nite-Out II should be stored in the refrigerator after opening.

In principle, there is nothing wrong with dosing the MICROBE-LIFT bacterial products with a dosing pump. However, this should have a back suction so that no residues remain in the corresponding hoses. Furthermore, it also applies here that you should only dose Special Blend, Thera P and Nite-Out II from the original bottle.

Our MICROBE-LIFT bacterial products can be kept for at least one year without refrigeration if stored properly (except for Nite-Out II, which must be placed in the refrigerator after opening).

No. Shake the MICROBE-LIFT® products before use and simply pour it into your aquarium.

When using the MICROBE-LIFT system, we recommend a weekly water change of 10 - 20%.

Tips & Tricks
  • Ensure sufficient carbonate hardness (KH) in order to accelerate the nitrification process.
  • Ozone and UV light can kill bacteria; please switch it off during the application for 12-24 hours.
  • Keep your skimmer on all the time to ensure adequate oxygenation, as bacteria also use oxygen.
  • Once opened, store Nite-Out II in the refrigerator between 4°C and 7°C.


Brackish water bacterial strains?

Nite-Out II contains brackish water bacterial strains, which have a key advantage over frequently used tropical bacterial strains: they already reach maximum performance at a water temperature of approx. 25°C, making them ideal for use in aquaria.

Product video

Can be optimally combined with

SPECIAL BLEND Water care bacteria


THERA P Animal Care Bacteria


AQUA BALANCE Nitrate Remover


GEL FILTER Filter Starter


XTREME Water Conditioner